Contraindicated (one)pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lessen panobinostat concentrations by ~70% and bring about cure failure. pentobarbital will lessen the extent or result of vinblastine by impacting hepatic/intestinal enzyme C